Research leads to new discoveries in medicine, helping improve care for patients in the future.

What is a clinical trial?

A clinical trial is a type of research study that helps develop new treatments and medications, with real people participating as volunteers.

Why is research important?

Clinical research helps develop and refine new approaches in healthcare. These discoveries shape future treatments and medical knowledge, advancing the care available in our community and beyond.

Who conducts clinical research?

At Kettering Health, research is performed by a team of experts—including physicians, advanced practice providers, nurses, pharmacists, and research coordinators.

To protect privacy and keep patients safe, every clinical trial is reviewed by an Institutional Review Board. These studies also follow strict rules from the National Institutes of Health and the US Food and Drug Administration.

How can you participate in research at Kettering Health?

To participate in research, ask your provider if clinical trials are a treatment option for you, or fill out the form below:

Our current trials

Study Category	Condition/Indication	Study Title	Principal Investigator
Cardiology	Acute coronary Syndrome (Heart Attack)	[LIBREXIA-ACS] A Phase 3, Randomized, Double-blind, Placebo-controlled, Event-driven Study to Demonstrate the Efficacy and Safety of Milvexian, an Oral Factor XIa Inhibitor, After a Recent Acute Coronary Syndrome	Dr. Franklin Handel
Cardiology	Aortic Valve Stenosis/TAVR Procedure	[EXPAND TAVR] Evolut™ EXPAND TAVR II Pivotal Trial	Dr. Brian Schwartz
Cardiology	Cardiovascular Disease	[Poseidon] Prevalence of systemic inflammation in patients with atherosclerotic cardiovascular disease and heart failure Disease Area	Dr. Franklin Handel
Cardiology	Mitral Regurgitation/Heart Failure	[EMPOWER] Assessment of the Carillon Mitral Contour System® in Treating Heart Failure with Functional Mitral Regurgitation	Dr. Brian Schwartz
Cardiology	Myocardial Infarction (Heart Attack)	[STEMI DTU] Primary Unloading and Delayed Reperfusion in ST-Elevation Myocardial Infarction	Dr. Raja Nazir
Cardiology	Myocardial Infarction (Heart Attack)	ARTEMIS – Effects of ziltivekimab versus placebo on cardiovascular outcomes in patients with acute myocardial infarction.	Dr. Franklin Handel
Cardiology	Pulmonary Embolism	[HI-PEITHO] A Randomized Trial of Ultrasound-facilitated, Catheter-directed, Thrombolysis Versus Anticoagulation for Acute Intermediate-high Risk Pulmonary Embolism: The Higher-risk Pulmonary Embolism Thrombolysis Study	Dr. Ammar Safar
Cardiology	Pulmonary Embolism	[Strike-PE] A Prospective, Multicenter Study of the IndigoTM Aspiration System Seeking to Evaluate the Long-Term Safety and Outcomes of Treating Pulmonary Embolism	Dr. Niranjan Reddy
Cardiology	Coronary Ischemia	CARDIOFLUX – A Registry of Cardiac PET and CardioFlux Magnetocardiography in Patients with Suspected Coronary Ischemia.	Dr. Damian Valencia
Neurology	Stroke	[OCEANIC-STROKE] A multicenter, randomized, placebo controlled, double-blind, parallel group and event driven Phase 3 study of the oral FXIa inhibitor asundexian (BAY 2433334) for the secondary prevention of ischemic stroke in adult patients with an acute non-cardioembolic ischemic stroke or high-risk TIA	Dr. Timothy Schoonover
Neurology	Knee Pain	[FREEDOM-1] Double-Blinded Randomized Control Trial of Knee Pain Utilizing Sub-Threshold Peripheral Nerve Stimulation	Dr. Nirmala Abraham
Oncology	Advanced Solid Tumors	[TAPUR] The Targeted Agent and Profiling Utilization Registry  Study	Dr. Malek Safa
Oncology	Brain Tumor	[STaRT] A Multicenter Observational Study of GammaTile™ Surgically Targeted Radiation Therapy in Intracranial Brain Neoplasms	Dr. Mark Hoeprich
Oncology	Brain Tumor	[REMASTer] REcurrent Brain Metastases After SRS Trial	Dr. Mark Hoeprich
Oncology	Cervical Cancer	[GOG-3043 ROCC] A Randomized Controlled Trial of Robotic versus Open Radical Hysterectomy for Early Stage Cervical Cancer	Dr. Thomas Reid
Oncology	Colorectal Cancer	MT2242 -Fresh Blood Samples from Patients with Colorectal Cancer (CRC) or Advanced Adenoma	Dr. Thomas Reid
Oncology	Glioblastoma Brain Tumor	[GESTALT] Feasibility study of resection and GammaTile followed by concomitant external beam radiation therapy (EBRT) and temozolomide (TMZ) and adjuvant TMZ in newly diagnosed glioblastoma (GBM).	Dr. Mark Hoeprich
Oncology	Glioma Brain Tumor	Telix-TLX-101-CDx-002 – EAP-FET – An Expanded Access Program for the non-invasive characterization of glioma or treatment related change utilizing Fluorine (F-18) floretyrosine (18F-FET, TLX101-CDx-002)	Dr. Mark Hoeprich
Oncology	Lung Cancer	[MERCK-LUNG] MK1084-004- A Phase 3, Randomized, Double-blind, Multicenter Study of MK-1084 in Combination With Pembrolizumab Compared With Pembrolizumab Plus Placebo as Firstline Treatment of Participants With KRAS G12C-Mutant, Metastatic NSCLC With PD-L1 TPS ≥50%	Dr. Alejandro Calvo
Oncology	Non-Small Cell Lung Cancer	MT4922-A – Frozen Blood Samples from Patients with Non-small Cell Lung Cancer (NSCLC)	Dr. Thomas Reid
Oncology	Ovarian Cancer	[GOG-3076 OnPrime] A Randomized Phase 3 Study Assessing the Efficacy and Safety of Olvi-Vec followed by Platinum-doublet Chemotherapy and Bevacizumab Compared with Platinum-doublet Chemotherapy and Bevacizumab in Women with Platinum-Resistant/Refractory Ovarian Cancer	Dr. Thomas Reid
Oncology	Ovarian Cancer	[GOG-3078 GLORIOSA] Randomized, multicenter, open-label, phase 3 study of mirvetuximab soravtansine in combination with bevacizumab versus bevacizumab alone as maintenance therapy for patients with FRα-positive recurrent platinum-sensitive epithelial ovarian, fallopian tube, or primary peritoneal cancers who have not progressed after second line platinum-based chemotherapy plus bevacizumab	Dr. Thomas Reid
Oncology	Ovarian Cancer	[GOG-3086 REFRAME] A Phase 2 Open-label Study Evaluating the Efficacy and Safety of Luveltamab Tazevibulin (STRO-002) in Women With Relapsed Platinum-resistant Epithelial Ovarian Cancer (Including Fallopian Tube or Primary Peritoneal Cancers) Expressing Folate Receptor Alpha (FOLR1)	Dr. Thomas Reid
Oncology	Ovarian Cancer & Pancreatic Cancer	MT1410-A Ovarian/Pancratic	Dr. Thomas Reid
Oncology	Pancreatic Cancer	MT2875 – Study of Fresh Blood & Urine from Patients with Pancreatic Cancer & High-Risk Controls	Dr. Thomas Reid
Oncology	Various Cancers	MT3060 – Biomarker Study in Fresh Blood of – Patients Scheduled to Receive I.O Therapy Keytruda (pembrolizumab)	Dr. Thomas Reid
Oncology	Renal Cell Carcinoma	[Telix FET EAP RCC] TLX 250 RCC An Expanded Access Program for the non-invasive detection of clear cell renal cell carcinoma (ccRCC) in patients with renal masses utilizing 89Zirconium-labelled girentuximab (89Zr-DFO-girentuximab)	Dr. Daniel Pucheril
Oncology	Solid Tumor	[STARBURST] Study of 89Zr-girentuximab for PET imaging of solid tumors likely to express high levels of CAIX	Dr. Arif Sheikh
Orthopedics	Carpal Tunnel Syndrome	[COMET-AOA] Pilot Study Evaluating the Elasticity and Shear Wave Modulus (Stiffness) of the Median Nerve in Patients With Mild to Moderate Idiopathic Carpal Tunnel Syndrome Receiving OMT and Conservative Therapy	Dr. Roland Gazaille
Primary Care	Urinary Tract Infections	[EMBRACE] Randomized, Double-blind, Placebo-controlled, Multicenter Phase 3 Study to Assess the Efficacy, Safety And Immunogenicity of Vaccination With ExPEC9V in the Prevention of Invasive Extraintestinal Pathogenic Escherichia coli Disease in Adults Aged 60 Years And Older with a History of Urinary Tract Infection in the Past 2 Years	Partnership with Kroger The Little Clinic

In addition to hosting clinical trials for cancer research, Kettering Health also collaborates with Dayton Clinical Oncology Program.